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Also, Zetia use may cause increased liver enzyme levels, especially if it’s taken with a statin drug. Increased liver enzymes can be a sign of liver damage. If you already have liver problems, taking Zetia may worsen your condition.Zetia has a well-documented safety profile. Zetia does not cause an increase or a decrease in blood pressure. No dosage adjustments are necessary for people with liver or kidney disease; however, Zetia should not be given to people with moderate to severe liver disease.However, the addition of ezetimibe to statin therapy has been associated with a slight increase in the likelihood of serum aminotransferase elevations or rates of discontinuation due to liver test abnormalities. Clinically apparent acute liver injury due to ezetimibe has been reported, but is rare.
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Is Zetia safe for the liver?
Zetia has a well-documented safety profile. Zetia does not cause an increase or a decrease in blood pressure. No dosage adjustments are necessary for people with liver or kidney disease; however, Zetia should not be given to people with moderate to severe liver disease.
Can ezetimibe cause elevated liver enzymes?
However, the addition of ezetimibe to statin therapy has been associated with a slight increase in the likelihood of serum aminotransferase elevations or rates of discontinuation due to liver test abnormalities. Clinically apparent acute liver injury due to ezetimibe has been reported, but is rare.
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Can ezetimibe affect liver function?
by Drugs.com
Yes, Zetia (ezetimibe) can cause liver damage, although it is very rare. Monitor liver enzymes for the development of serious toxic hepatitis and consider ezetimibe discontinuation if it develops.
What are the long term side effects of Zetia?
You may experience muscle problems as a side effect of Zetia. These problems can include muscle pain and muscle weakness, and rarely, muscle breakdown. You may also have muscle cramps, spasms, or stiffness. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs.
Does Zetia help fatty liver?
That study showed that combination treatment with ezetimibe and a statin is safe and effective for improving liver enzyme levels. Taken together, these studies suggest that ezetimibe treatment has benefits in normalizing liver enzyme levels and improving hepatic steatosis.
Is Zetia safe long term?
While Zetia is safe for most patients, doctors should carefully monitor patients for liver damage, he said. “I think other cases will emerge,” he said. When the F.D.A. approved Zetia in 2002, it relied on trials that covered only 3,900 patients and lasted no more than 12 weeks.
Who should not take ezetimibe?
Not approved for use by anyone younger than 10 years old. You should not use ezetimibe with a “statin” cholesterol medicine (Zocor, Lipitor, Crestor, and others) if: you have active liver disease; you are pregnant; or.
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Can Zetia (ezetimibe) cause liver damage? – Drugs.com
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What are the side effects of ezetimibe 10 mg?
- cough.
- diarrhea.
- fatigue.
- headache.
- increased alanine aminotransferase (ALT)
- increased gamma-glutamyl transferase (GGT)
- increased liver transaminases (with HMG-CoA reductase inhibitors; greater than 3 times upper limit of normal; 1%)
- influenza.
Where is Zetia metabolized?
Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation (a phase II reaction) with subsequent biliary and renal excretion. Minimal oxidative metabolism (a phase I reaction) has been observed in all species evaluated.
Should ezetimibe be taken at night?
There is no specific time of the day that is best to take ezetimibe, as it works exactly the same whether you take in the morning, afternoon or at night. Ezetimibe is taken once a day, at the same time each day and it can be taken with or without food.
Can ezetimibe cause weight gain?
Ezetimibe does not cause weight gain or weight loss. Ezetimibe has a well documented safety profile. Ezetimibe has low risk for the side effect of muscle ache and pains.
Can you drink alcohol with ezetimibe?
There are no special prohibitions against drinking alcoholic beverages if you take ezetimibe and simvastatin. In fact, modest amounts of alcohol (no more than one drink per day for women, no more than two drinks daily for men) can increase levels of HDL cholesterol, the “good” kind.
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What is the best cholesterol medication with the least side effects?
In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications. They also found that lower doses produced fewer side effects in general.
What happens if you stop taking Zetia?
If you stop taking the drug or don’t take it at all: Your cholesterol level may rise. If your cholesterol is high and not controlled for a long time, you can have narrowing of the arteries. This may lead to a heart attack or stroke.
Can Zetia cause pancreatitis?
Serious side effects of ezetimibe include hypersensitivity reactions (including angioedema – swelling of the skin and underlying tissues of the head and neck – that can be life-threatening), skin rash, nausea, pancreatitis, muscle damage (myopathy or rhabdomyolysis), and hepatitis.
Can ezetimibe cause fatty liver?
…
Table 1.
| Drug (s) | Parameter |
|---|---|
| ↓ALT | |
| ↓hsCRP | |
| ↓Steatosis grade and NAFLD activity score | |
| Ezetimibe plus weight loss[17] | ↓Intrahepatic triglyceride content |
Does Zetia affect your kidneys?
Can Zetia (ezetimibe) cause kidney damage? Rarely, Zetia (ezetimibe) can cause a breakdown in muscle tissue, which can lead to kidney failure. This risk is increased when you take Zetia (ezetimibe) with higher doses of statins, are over 65 years old, have low thyroid, or have kidney problems.
Can Zetia be taken without a statin?
Official Answer. No, Zetia is not a statin drug. Zetia reduces blood cholesterol in a different way to statin medications. Zetia lowers cholesterol levels by decreasing the amount of cholesterol that is absorbed from the small intestine, so that there is less intestinal cholesterol delivered to the liver.
Should I take CoQ10 with ezetimibe?
No interactions were found between CoQ10 and ezetimibe. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Is Zetia better than statins?
Official Answer. Whether Zetia is better or worse than a statin at reducing cholesterol depends on the individual patient. Zetia and statins reduce cholesterol each with their own different mode of action.
What is the best time of day to take Zetia?
Official Answer. There is no best time to take Zetia, as it works exactly the same whether you take it in the morning, afternoon or evening. Zetia is taken once a day, at the same time each day and it can be taken with or without food.
Does ezetimibe cause dementia?
Official Answer. Memory loss is not a side effect of Zetia (ezetimibe) when it is used alone to treat high cholesterol. Zetia is often used with other cholesterol lowering medications like statins which have been linked with cognitive impairment (memory loss, forgetfulness, or confusion).
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What is the best non statin drug for cholesterol?
There are many non-statin medications your doctor might prescribe: Bile acid-binding resins, like cholestyramine (Locholest, Prevalite, Questran), colesevelam (WelChol), and colestipol (Colestid) stick to cholesterol-rich bile acids in your intestines and lower your LDL levels.
What can I take instead of statins to lower cholesterol?
- Fibrates. Mostly used for lowering triglyceride levels in patients whose levels are very high and could cause pancreatitis. …
- Plant stanols and sterols. …
- Cholestyramine and other bile acid-binding resins. …
- Niacin. …
- Policosanol. …
- Red yeast rice extract (RYRE) …
- Natural products.
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